Effect of Atorvastatin on Hematologic Parameters in Patients With Hypercholesterolemia. (November 2013)

• Record Type: Journal Article
• Authors: Akın, Fatih; Ayça, Burak; Köse, Nuri; Şahin, Irfan; Akin, Melike Nur; Canbek, Tuğba Dübektaş; Güngör, Ömer
• Is Part Of: Angiology. Volume 64:Number 8(2013)
• Page Start: 621
• Page End: 625
• Publication Date: 2013-11
• Subjects: atorvastatin -- mean platelet volume -- red cell distribution width -- neutrophil to lymphocyte ratio; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319713479154
• Languages: English
• ISSNs: 0003-3197

Abstract

Hematologic parameters such as mean platelet volume (MPV), red cell distribution width (RDW), and neutrophil to lymphocyte (N/L) ratio are associated with increased cardiovascular risk. We investigated the effect of atorvastatin on hematologic parameters in patients with hypercholesterolemia. A total of 79 patients with hypercholesterolemia and 47 normocholesterolemic healthy participants were included. Patients with hypercholesterolemia received 10 to 80 mg/d atorvastatin during a 24-week period. Hematologic parameters were measured at baseline and after 6 months. Atorvastatin treatment produced a significant decrease in MPV levels (9.3 ± 1.3 vs 9.1 ± 1.2 fL, P = .008) and platelet count (259 ± 61 vs 248 ± 51 10 9 /L, P = .005). The N/L ratio decreased significantly after atorvastatin treatment from 2.9 ± 1.2 to 2.6 ± 1.1, ( P = .014). The RDW and platelet distribution width levels were not different among the study groups, before and after treatment. Atorvastatin may beneficially reduce MPV levels and N/L ratio. This antiplatelet and anti-inflammatory effect of atorvastatin treatment could play a role in reducing cardiovascular risk.