The Association Between Small Vessel Infarcts and the Activities of Amyloid-β Peptide Degrading Proteases in Apolipoprotein E4 AlleleCarriers. (November 2013)

• Record Type: Journal Article
• Authors: Zhu, Haihao; Bhadelia, Rafeeque A.; Liu, Zhiheng; Vu, Linh; Li, Huajie; Scott, Tammy; Bergethon, Peter; Mwamburi, Mkaya; Rosenzweig, James L.; Rosenberg, Irwine; Qiu, Wei Qiao
• Is Part Of: Angiology. Volume 64:Number 8(2013)
• Page Start: 614
• Page End: 620
• Publication Date: 2013-11
• Subjects: small vessel brain infarct -- apolipoprotein E4 allele -- substrate V degradation; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319712462125
• Languages: English
• ISSNs: 0003-3197

Abstract

Small vessel (SV) and large vessel (LV) brain infarcts are distinct pathologies. Using a homebound elderly sample, the numbers of either infarct subtypes were similar between those apolipoprotein E4 allele (ApoE4) carriers (n = 80) and noncarriers (n = 243). We found that the higher the number of SV infarcts, but not LV infarcts, a participant had, the higher the activity of substrate V degradation in serum especially among ApoE4 carriers (β = +0.154, SE = 0.031, P < .0001) after adjusting for the confounders. Since substrate V degradation could be mediated by insulin-degrading enzyme (IDE) or/and angiotensin-converting enzyme (ACE), but no relationship was found between SV infarcts and specific ACE activities, blood IDE may be a useful biomarker to distinguish the brain infarct subtypes. Insulin-degrading enzyme in blood may also imply an important biomarker and a pathological event in Alzheimer disease through SV infarcts in the presence of ApoE4.