Evaluation of denoising strategies for task‐based functional connectivity: Equalizing residual motion artifacts between rest and cognitively demanding tasks. Issue 6 (2nd February 2021)

• Record Type: Journal Article
• Authors: Mascali, Daniele; Moraschi, Marta; DiNuzzo, Mauro; Tommasin, Silvia; Fratini, Michela; Gili, Tommaso; Wise, Richard G.; Mangia, Silvia; Macaluso, Emiliano; Giove, Federico
• Is Part Of: Human brain mapping. Volume 42:Issue 6(2021)
• Page Start: 1805
• Page End: 1828
• Publication Date: 2021-02-02
• Subjects: artifact -- denoising -- functional connectivity -- motion -- resting‐state fMRI -- task‐concurrent connectivity; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25332
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: In‐scanner head motion represents a major confounding factor in functional connectivity studies and it raises particular concerns when motion correlates with the effect of interest. One such instance regards research focused on functional connectivity modulations induced by sustained cognitively demanding tasks. Indeed, cognitive engagement is generally associated with substantially lower in‐scanner movement compared with unconstrained, or minimally constrained, conditions. Consequently, the reliability of condition‐dependent changes in functional connectivity relies on effective denoising strategies. In this study, we evaluated the ability of common denoising pipelines to minimize and balance residual motion‐related artifacts between resting‐state and task conditions. Denoising pipelines—including realignment/tissue‐based regression, PCA/ICA‐based methods (aCompCor and ICA‐AROMA, respectively), global signal regression, and censoring of motion‐contaminated volumes—were evaluated according to a set of benchmarks designed to assess either residual artifacts or network identifiability. We found a marked heterogeneity in pipeline performance, with many approaches showing a differential efficacy between rest and task conditions. The most effective approaches included aCompCor, optimized to increase the noise prediction power of the extracted confounding signals, and global signal regression, although both strategies performed poorly in mitigating the spurious distance‐dependent association between motion and connectivity. Censoring was the only approach that substantially reduced distance‐dependent artifacts, yet this came at the great cost of reduced network identifiability. The implications of these findings for best practice in denoising task‐based functional connectivity data, and more generally for resting‐state data, are discussed. Abstract : We showed the inefficacy of many denoising strategies in balancing motion‐related artifacts between functional conditions that are differently prone to motion, such as rest and cognitively demanding conditions. While no pipeline was able to completely suppress motion artifacts and simultaneously maximize network identifiability, we found that strategies exploiting an optimized aCompCor yielded the best results. Importantly, we advocate the use of censoring with caution, since we found the method to be cost ineffective, prone to introduce biases and to reduce network identifiability.