Incidence and predictors of early and late target lesion revascularization after everolimus‐eluting stent implantation in unselected patients in japan. Issue 1 (15th March 2017)

• Record Type: Journal Article
• Authors: Kurihara, Ken; Ashikaga, Takashi; Sasaoka, Taro; Yoshikawa, Shunji; Isobe, Mitsuaki
• Is Part Of: Catheterization and cardiovascular interventions. Volume 90:Issue 1(2017)
• Page Start: 78
• Page End: 86
• Publication Date: 2017-03-15
• Subjects: late catch‐up phenomenon -- drug‐eluting stent -- target lesion failure; Heart -- Diseases -- Diagnosis -- Periodicals; Cardiac catheterization -- Periodicals; 616.1207572
• DOI: 10.1002/ccd.26964
• Languages: English
• ISSNs: 1522-1946

Abstract

Abstract : Objective: The objective of this study was to clarify the incidence and predictors of early and late target lesion revascularization (TLR) after everolimus‐eluting stent (EES) implantation in actual clinical practice. Background: Several clinical studies have reported the incidence and predictors of TLR after EES implantation. However, detailed features of early and late TLR are unknown. Methods: We analyzed the clinical data of patients who underwent EES implantation between January 2010 and December 2011 at 22 institutions in Japan (Tokyo‐MD PCI study). Patients who underwent ischemia‐driven TLR (ID‐TLR) were grouped according to the number of years elapsed since stent placement, and incidence and correlations between clinical factors were analyzed. Results: Statistical analysis was performed for 1, 899 patients and 2, 305 lesions. The mean age was 70.0 ± 9.9 years, and the median follow‐up period was 1, 281 days (IQR: 762–1, 440 days). The incidence of ID‐TLR was 2.7% at 1 year and 5.4% at 4 years. After 2 years, the ID‐TLR rates plateaued. The independent predictors of ID‐TLR occurring within 2 years were hemodialysis, triple vessel disease, restenotic lesion, and ostial lesions. The independent predictors of ID‐TLR between 2 and 4 years were diabetes mellitus and peripheral artery disease. Conclusion: The ID‐TLR rates leveled off after 2 years. Furthermore, the predictors of ID‐TLR that occurred within 2 years of EES implantation differed from those that occurred later than 2 years. © 2017 Wiley Periodicals, Inc.