An Analysis of the Relationship Between Ankle–Brachial Index and Estimated Glomerular Filtration Rate in Type 2 Diabetes. (April 2013)

• Record Type: Journal Article
• Authors: Jin, Xing; Ma, Jian-hua; Shen, Yun; Luo, Yong; Su, Xiao-fei; Chen, Ying-yue; Qi, Shao-kang; Wu, Jin-dan
• Is Part Of: Angiology. Volume 64:Number 3(2013)
• Page Start: 237
• Page End: 241
• Publication Date: 2013-04
• Subjects: type 2 diabetes -- ankle–brachial index -- glomerular filtration rate; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319712464515
• Languages: English
• ISSNs: 0003-3197

Abstract

We investigated the relationship between peripheral arterial disease (PAD) and renal function in patients with type 2 diabetes mellitus (T2DM). We enrolled 2057 hospitalized patients with T2DM and measured kidney function and ankle–brachial index (ABI). The estimated glomerular filtration rate (eGFR) was derived using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and ABI was grouped as low (<0.9), low-normal (0.9-1.09), normal (1.1-1.3), and high (>1.3). Logistic regression was used to evaluate the associations of eGFR with ABI. Generally speaking, the ABI was negatively correlated with systolic blood pressure, fasting C-peptide, total cholesterol, and low-density lipoprotein cholesterol while positively correlated with body mass index ( P < .05 to <.01). Only a low ABI was positively correlated with eGFR ( P < .01). In addition to the association of the ABI with cardiovascular events, stroke, and PAD, ABI may also predict the change in renal function in patients with T2DM.