Extended‐amygdala intrinsic functional connectivity networks: A population study. Issue 6 (12th December 2020)

• Record Type: Journal Article
• Authors: Berry, Samuel C.; Wise, Richard G.; Lawrence, Andrew D.; Lancaster, Thomas M.
• Is Part Of: Human brain mapping. Volume 42:Issue 6(2021)
• Page Start: 1594
• Page End: 1616
• Publication Date: 2020-12-12
• Subjects: alcohol use -- bed nucleus of the stria terminalis (BST/BNST) -- central nucleus of the amygdala (CeA) -- dispositional negativity -- extended amygdala (ExtA) -- intrinsic functional connectivity (iFC) -- task‐free functional magnetic resonance imaging (tf‐fMRI); Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25314
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: Pre‐clinical and human neuroimaging research implicates the extended‐amygdala (ExtA) (including the bed nucleus of the stria terminalis [BST] and central nucleus of the amygdala [CeA]) in networks mediating negative emotional states associated with stress and substance‐use behaviours. The extent to which individual ExtA structures form a functionally integrated unit is controversial. We utilised a large sample ( n > 1, 000 healthy young adult humans) to compare the intrinsic functional connectivity networks (ICNs) of the BST and CeA using task‐free functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. We assessed whether inter‐individual differences within these ICNs were related to two principal components representing negative disposition and alcohol use. Building on recent primate evidence, we tested whether within BST‐CeA intrinsic functional connectivity (iFC) was heritable and further examined co‐heritability with our principal components. We demonstrate the BST and CeA to have discrete, but largely overlapping ICNs similar to previous findings. We found no evidence that within BST—CeA iFC was heritable; however, post hoc analyses found significant BST iFC heritability with the broader superficial and centromedial amygdala regions. There were no significant correlations or co‐heritability associations with our principal components either across the ICNs or for specific BST‐Amygdala iFC. Possible differences in phenotype associations across task‐free, task‐based, and clinical fMRI are discussed, along with suggestions for more causal investigative paradigms that make use of the now well‐established ExtA ICNs. Abstract : We examine the intrinsic connectivity networks of two key nodes within the extended amygdala in a large human sample. We find no associations within this network with principal components related to negative disposition or alcohol use traits. We report heritable intrinsic functional connections between the bed nucleus of the stria terminalis (BST) and the centromedial and superficial amygdala regions; however, do not repeat a recent non‐human primate finding of a heritable connection between the BST and central nucleus of the amygdala.