Nanocarrier with self‐antioxidative property for stabilizing and delivering ascorbyl palmitate into skin. Issue 8 (17th June 2013)

• Record Type: Journal Article
• Authors: Janesirisakule, Sirinapa; Sinthusake, Tarit; Wanichwecharungruang, Supason
• Is Part Of: Journal of pharmaceutical sciences. Volume 102:Issue 8(2013:Aug.)
• Page Start: 2770
• Page End: 2779
• Publication Date: 2013-06-17
• Subjects: curcumin -- antioxidant -- ascorbyl palmitate -- skin delivery -- polymeric drug carrier -- nanoparticles -- transdermal drug delivery -- skin -- stability; Pharmacy -- Periodicals; 615.1
• DOI: 10.1002/jps.23641
• Languages: English
• ISSNs: 0022-3549

Abstract

Abstract: The concept of a nanocarrier with a self‐antioxidative property to deliver and stabilize a labile drug while at the same time providing a free radical scavenging activity is demonstrated. Curcumin was grafted onto a poly(vinyl alcohol) [PV(OH)] chain, and the nanocarriers fabricated from the obtained curcumin‐grafted PV(OH) polymer [CUR‐PV(OH)] showed a good free radical scavenging activity. Ascorbyl palmitate (AP) could be effectively loaded into the CUR‐PV(OH) at 29% by weight. The CUR‐PV(OH)‐encapsulated AP was 77% more stable than the free (unencapsulated) AP, and 47% more stable than AP encapsulated in the control nanocarrier with no antioxidative property [cinnamoyl‐grafted PV(OH); CIN‐PV(OH)]. Although coencapsulation of curcumin and AP into CIN‐PV(OH) showed some improvement on the AP stability, AP was more stable when encapsulated in CUR‐PV(OH). Compared with the free AP, encapsulated AP within the CUR‐PV(OH) nanocarriers showed not only a better penetration into pig skin dermis via hair follicle pathway followed by the release and diffusion of the AP, but also a greater AP stability after skin application. Although a proof of principle is shown for CUR‐PV(OH) and AP, it is likely that other carriers of the same principal could be designed and applied to different oxidation‐sensitive drugs. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2770–2779, 2013