Measurements of immature platelet fraction and inflammatory markers in atrial fibrillation patients ‐ Does persistency or ablation affect results?. (8th December 2020)

• Record Type: Journal Article
• Authors: Perelshtein Brezinov, Olga; Sevylia, Ziv; Rahkovich, Michael; Kakzanov, Yana; Yahud, Ella; Fortis, Lior; Kogan, Yonatan; Asher, Elad; Lev, Eli; Laish‐Farkash, Avishag
• Is Part Of: International journal of laboratory hematology. Volume 43:Number 4(2021)
• Page Start: 602
• Page End: 608
• Publication Date: 2020-12-08
• Subjects: atrial fibrillation -- cryoballoon ablation -- immature platelet fraction -- inflammation -- pulmonary vein isolation -- thrombosis; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; 616.15005
• DOI: 10.1111/ijlh.13426
• Languages: English
• ISSNs: 1751-5521

Abstract

Abstract: Purpose: Atrial fibrillation (AF) is associated with platelet hyperactivity and a higher proportion of immature platelets. We aimed to examine whether immature platelet fraction (IPF) and inflammatory markers differ between AF types and whether they are affected by ablation. Methods: A prospective study included patients with atrial fibrillation/flutter (AFL). We excluded patients with hematologic, inflammatory, or acute coronary states. Blood samples for IPF, white blood cells (WBC), neutrophil‐to‐lymphocyte ratio (NLR), and C‐reactive protein (CRP) were collected at baseline, within one‐hour postablation in those undergoing ablations, and the day after ablation. IPF was measured by an autoanalyzer (Sysmex 2100 XE). Results: One hundred and four patients were included (paroxysmal AF‐63, persistent AF‐36, AF and AFL‐7, AFL alone‐5), (Mean age 67.7 ± 12.8 years, 54.8% male, CHA2 D2 ‐VASC2 3.2 ± 1.8). Seventy‐two patients underwent ablation (cryoballoon AF ablation‐60, AFL radiofrequency ablation‐5, both‐7). There was no difference between paroxysmal and persistent AF regarding baseline markers. There was a significant change in the following parameters after ablation: WBC (baseline 6.9 ± 2.0, 1‐h post 8.0 ± 2.4, and 1‐day post 9.0 ± 2.8 ×10 9 /L), NLR (2.9 ± 2.2, 3.0 ± 2.4, 4.2 ± 2.9, respectively), and CRP (3.6 ± 3.7, 3.6 ± 3.5, 12.4 ± 9.0 mg/L, respectively) ( P < .05 for all). However, there were no differences in immature platelet count (8.6 ± 4.8, 8.5 ± 4.9, 8.4 ± 5.2 ×10 9 /L) or IPF (4.6 ± 3.2, 4.7 ± 3.3, 4.9 ± 3.6%) from baseline to postablation (p = NS). Conclusions: AF persistency does not affect IPF and inflammation. In patients undergoing cryoablation of AF, there is a postablation inflammatory process; however, platelet activation is probably not affected.