A novel 3D Tesla valve micromixer for efficient mixing and chitosan nanoparticle production. Issue 21 (3rd August 2022)

• Record Type: Journal Article
• Authors: Guo, Kefan; Chen, Yao; Zhou, Zheng; Zhu, Shu; Ni, Zhonghua; Xiang, Nan
• Other Names: Xuan Xiangchun guestEditor.; Yang Chun guestEditor.
• Is Part Of: Electrophoresis. Volume 43:Issue 21/22(2022)
• Page Start: 2184
• Page End: 2194
• Publication Date: 2022-08-03
• Subjects: chitosan nanoparticles synthesis -- micromixing -- Tesla valve micromixer -- viscoelastic solution; Electrophoresis -- Periodicals; Electrophoresis -- Periodicals; 541.372
• DOI: 10.1002/elps.202200077
• Languages: English
• ISSNs: 0173-0835

Abstract

Abstract: Current three‐dimensional micromixers for continuous flow reactions and nanoparticle synthesis are complex in structure and difficult to fabricate. This paper investigates the design, fabrication, and characterization of a novel micromixer that uses a simple spatial Tesla valve design to achieve efficient mixing of multiple solutions. The flow characteristics and mixing efficiencies of our Tesla valve micromixer are investigated using a combination of numerical simulations and experiments. The results show that in a wide range of flow rates, viscoelastic solutions with different concentrations can be well mixed in our micromixer. Finally, experiments on the synthesis of chitosan nanoparticles are conducted to verify the practicability of our micromixer. Compared with nanoparticles prepared by conventional magnetic stirring, the size of nanoparticles prepared by micromixing is smaller and the distribution is more uniform. Therefore, our Tesla valve micromixer has significant advantages and implications for mixing chemical and biological reactions.