Enhancing signals of microfluidic impedance cytometry through optimization of microelectrode array. Issue 21 (20th April 2022)

• Record Type: Journal Article
• Authors: Zhou, Chenyang; Shen, Hailong; Feng, Huicheng; Yan, Zhibin; Ji, Bowen; Yuan, Xichen; Zhang, Ruirong; Chang, Honglong
• Other Names: Xuan Xiangchun guestEditor.; Yang Chun guestEditor.
• Is Part Of: Electrophoresis. Volume 43:Issue 21/22(2022)
• Page Start: 2156
• Page End: 2164
• Publication Date: 2022-04-20
• Subjects: impedance cytometry -- microfluidics -- single‐cell analysis; Electrophoresis -- Periodicals; Electrophoresis -- Periodicals; 541.372
• DOI: 10.1002/elps.202100351
• Languages: English
• ISSNs: 0173-0835

Abstract

Abstract: Microfluidic impedance cytometry shows a great value in biomedical diagnosis. However, the crosstalk between neighboring microelectrodes strongly weakens the impedance signal. Hereby, we demonstrate a novel microfluidic impedance cytometer consisted of sensing electrodes and ground electrodes (GNDs). The simulation reveals a signal enhancement by more than five times with GNDs compared to that without ones. We also found that the linear correlation between the impedance at a high frequency and that at a low frequency varies as microparticle size changes, which can be used for microparticle classification. The study can help with microelectrode optimization and signal processing for microfluidic impedance analysis.