Recent Advances in Stereocontrolled Mannosylation: Focus on Glycans Comprising Acidic and/or Amino Sugars. Issue 11 (18th October 2021)

• Record Type: Journal Article
• Authors: Alex, Catherine; Demchenko, Alexei V.
• Is Part Of: Chemical record. Volume 21:Issue 11(2021)
• Page Start: 3278
• Page End: 3294
• Publication Date: 2021-10-18
• Subjects: mannosides -- glycosylation -- oligosaccharides -- stereoselective synthesis -- glycans; Chemistry -- Periodicals; 540
• DOI: 10.1002/tcr.202100201
• Languages: English
• ISSNs: 1527-8999

Abstract

Abstract: The main focus of this review is to describe accomplishments made in the stereoselective synthesis of β ‐linked mannosides functionalized with carboxyls or amines/amides. These ManNAc, ManA and ManNAcA residues found in many glycoconjugates, bacterial polysaccharides, and alginates have consistently captured interest of the glycoscience community both due to synthetic challenge and therapeutic potential. Abstract : The main focus of this review is to describe accomplishments made in the stereoselective synthesis of glycosides and oligosaccharides containing β ‐mannosides functionalized with carboxyls or amines/amides.