Three Previously Undescribed Chlorophenyl Glycosides from the Bulbs of Lilium regale. Issue 10 (2nd September 2021)

• Record Type: Journal Article
• Authors: Yan, Jie; Guo, Wenxiu; Zhou, Lanyu; Guo, Dale; Pei, Jin; Deng, Yun; Zheng, Haoyuan; Liu, Ding; Xie, Xiaofang; Peng, Cheng
• Is Part Of: Chemistry & biodiversity. Volume 18:Issue 10(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-02
• Subjects: Lilium regale -- chlorophenyl glycosides -- structural elucidation -- anti-proliferative activity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202100403
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Three previously undescribed chlorophenyl glycosides, (2, 4, 6‐trichloro‐3‐hydroxy‐5‐methoxyphenyl)methyl β‐D‐glucopyranoside (1 ), (2, 4‐dichloro‐3, 5‐dimethoxyphenyl)methyl 6‐ O ‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside (2 ) and 4‐chloro‐3‐methoxy‐5‐methylphenyl 6‐ O ‐(6‐deoxy‐β‐L‐mannopyranosyl)‐β‐D‐glucopyranoside (3 ) were obtained from Lilium regale . The absolute configurations of these new finds were elucidated by comprehensive analyses of spectroscopic data combined with acid hydrolysis derivatization. (2, 4‐dichloro‐3, 5‐dimethoxyphenyl)methyl 6‐ O ‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside (2 ) can inhibit the proliferation of lung carcinoma A549 cells with an IC50 value of 29 μΜ. Abstract :