Inside Cover: Gausemycins A, B: Cyclic Lipoglycopeptides from Streptomyces sp. (Angew. Chem. Int. Ed. 34/2021). Issue 34 (21st June 2021)

• Record Type: Journal Article
• Authors: Tyurin, Anton P.; Alferova, Vera A.; Paramonov, Alexander S.; Shuvalov, Maxim V.; Kudryakova, Gulnara K.; Rogozhin, Eugene A.; Zherebker, Alexander Y.; Brylev, Vladimir A.; Chistov, Alexey A.; Baranova, Anna A.; Biryukov, Mikhail V.; Ivanov, Igor A.; Prokhorenko, Igor A.; Grammatikova, Natalia E.; Kravchenko, Tatyana V.; Isakova, Elena B.; Mirchink, Elena P.; Gladkikh, Elena G.; Svirshchevskaya, Elena V.; Mardanov, Andrey V.; Beletsky, Aleksey V.; Kocharovskaya, Milita V.; Kulyaeva, Valeriya V.; Shashkov, Alexander S.; Tsvetkov, Dmitry E.; Nifantiev, Nikolay E.; Apt, Alexander S.; Majorov, Konstantin B.; Efimova, Svetlana S.; Ravin, Nikolai V.; Nikolaev, Evgeny N.; Ostroumova, Olga S.; Katrukha, Genrikh S.; Lapchinskaya, Olda A.; Dontsova, Olga A.; Terekhov, Stanislav S.; Osterman, Ilya A.; Shenkarev, Zakhar O.; Korshun, Vladimir A.;
• Is Part Of: Angewandte Chemie international edition. Volume 60:Issue 34(2021)
• Page Start: 18350
• Page End: 18350
• Publication Date: 2021-06-21
• Subjects: antibacterial activity -- antibiotics -- biosynthesis -- lipoglycopeptides -- structure elucidation; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202107693
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : A new lipoglycopeptide antibiotic family with unique structural features and pronounced activity against Gram‐positive bacteria is described by Stanislav S. Terekhov, Zakhar O. Shenkarev, Vladimir A. Korshun, and co‐workers in their Research Article on page 18694 . Gausemycins are intrinsically fluorescent compounds with an original mode of antibacterial action. Analysis of the biosynthetic gene cluster revealed unusual enzymology, involved in the formation of a previously unknown nonproteinogenic amino acid.