Epigenetic regulation in antiviral innate immunity. Issue 7 (27th May 2021)

• Record Type: Journal Article
• Authors: Wang, Xiao; Xia, Huawei; Liu, Shengde; Cao, Lili; You, Fuping
• Is Part Of: European journal of immunology. Volume 51:Issue 7(2021)
• Page Start: 1641
• Page End: 1651
• Publication Date: 2021-05-27
• Subjects: Antiviral innate immunity -- Chromatin remodeling -- Epigenetics -- Histone modification -- m6A; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.202048975
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract: Emerging life‐threatening viruses have posed great challenges to public health. It is now increasingly clear that epigenetics plays a role in shaping host‐virus interactions and there is a great need for a more thorough understanding of these intricate interactions through the epigenetic lens, which may represent potential therapeutic opportunities in the clinic. In this review, we highlight the current understanding of the roles of key epigenetic regulators — chromatin remodeling and histone modification — in modulating chromatin openness during host defense against virus. We also discuss how the RNA modification m6A ( N 6‐methyladenosine) affects fundamental aspects of host‐virus interactions. We conclude with future directions for uncovering more detailed functions that epigenetic regulation exerts on both host cells and viruses during infection. Abstract : Epigenetic regulation is actively involved in host defense against virus. Here, we summarize the current understanding of the roles of chromatin remodeling and histone modification in modulating chromatin openness as well as how m6A shapes host‐virus interactions during viral infection.