A probability formula derived from serum indicators, age, and comorbidities as an early predictor of dementia in elderly Chinese people. Issue 8 (26th June 2021)

• Record Type: Journal Article
• Authors: Gong, Qing; Xie, Lianhong; Bi, Minghui; Yu, Lina
• Is Part Of: Brain and behavior. Volume 11:Issue 8(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-26
• Subjects: dementia -- elderly screen -- homocysteine -- low‐density lipoproteins -- total cholesterol; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.2236
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Introduction: Blood‐based indicators are potentially economical and a safe method for screening a population for dementia, although their predictive values have not been unequivocally confirmed. The present study proposes a dementia prediction formula based on serum indicators and patient characteristics. Methods: From January 2016 to December 2018, the data of elderly patients older than 60 years admitted to the Department of Neurology and Geriatrics in our hospital were retrospectively reviewed. A multivariate logistic regression model was applied to verify the patients' characteristics and serum indicators associated with the risk of dementia. After receiver‐operating characteristic (ROC) curve and area under the ROC curve (AUC) analyses, we propose a dementia prediction formula and cutoff values for the predictive ability of early dementia. Results: Four thousand seven hundred twenty two elderly patients were enrolled, and the incidence of dementia was 12.0% (565). When patients had ≥8 comorbidities, their risk of developing dementia was 20 times higher than those without comorbidities. After multivariate regression analysis, age (OR: 1.086, p < .001) and homocysteine (HCY) concentrations (OR: 1.017, p = .003) were proven to be linked to the risk of developing dementia, while total cholesterol (TC) (OR: 0.674, p = .005) was a protective factor for dementia. We developed a formula of age + low‐density lipoprotein cholesterol (LDL‐C) + TC + HCY + number of comorbidities as a good predictor of dementia (AUC: 0.79), with a probability (cutoff) value of 0.112 (sensitivity 87.4%, specificity 55.8%, and accuracy 60.5%). Conclusions: High‐serum HCY and low TC were risk factors for developing dementia. A cutoff value > 0.112 derived from our formula was an excellent predictor for people at a high risk of developing dementia, and may be a potentially useful diagnostic tool for identifying patients at risk for dementia in routine clinical practice. Abstract :