Biophysical insights into the binding capability of Cu(II) schiff base complex with BSA protein and cytotoxicity studies against SiHa. Issue 11 (November 2022)

• Record Type: Journal Article
• Authors: Maity, Minakshi; Pramanik, Ushasi; Hathwar, Venkatesha R.; Brandao, Paula; Mukherjee, Saptarshi; Maity, Swapan; Maity, Ribhu; Maity, Tithi; Chandra Samanta, Bidhan
• Is Part Of: Heliyon. Volume 8:Issue 11(2022)
• Publication Date: 2022-11
• Subjects: BSA quencher -- Cu(II) complex -- Cytotoxicity -- Schiff base -- SiHa cancer cell; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2022.e11345
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: Herein, we have explored the effects of chlorinated mononuclear Cu(II) complex upon binding with BSA protein (bovine serum albumin) and its in vitro anti-proliferative potentiality against SiHa cell. The complex was synthesized involving a Schiff base ligand having N, N, O donor centers and characterized by several spectroscopic studies. Structure, DFT studies and Hirshfeld surface (HS) analyses were identified using crystallographic computational studies. The binding interaction with BSA depicts the efficacy of the complex towards promising binding of it with BSA. Further, the complex shows a moderate cytotoxicity against SiHa cancer cell signifying its potentiality as an anti-proliferative agent for human cervix uteri carcinoma. Graphical abstract: Image 1 Highlights: Cu(II) Schiff base with four co-ordinations forms distorted square planar geometry. The complex can act as promising BSA quencher. Cytotoxicity of the complex against SiHa cell by MTT assay. Potential as an anti-cancer drug for human cervix uteri carcinoma. Abstract : BSA quencher; Cu(II) complex; Cytotoxicity; Schiff base; SiHa cancer cell.