Fabrication of Cellulosic Nonwoven-Based Wound Dressings Coated with CTAB-Loaded Double Network PAMPS/PNaA Hydrogels. Issue 16 (28th November 2022)

• Record Type: Journal Article
• Authors: Sadeghianmaryan, Ali; Naghieh, Saman; Salimi, Ali; Kabiri, Kourosh; Cella, Monica A; Ahmadi, Ali
• Is Part Of: Journal of natural fibers. Volume 19:Issue 16(2022)
• Page Start: 12718
• Page End: 12735
• Publication Date: 2022-11-28
• Subjects: Cellulosic nonwoven-based wound dressing -- double network hydrogel -- CTAB-based antibacterial activity -- aspirin delivery -- cell viability -- cotton nonwoven; 纤维素非织造伤口敷料 -- 双网络水凝胶 -- 基于CTAB的抗菌活性 -- 阿司匹林递送 -- 细胞活力 -- 棉非织造布; Textile research -- Periodicals; Textile research; Periodicals; 677.005
• DOI: 10.1080/15440478.2022.2073505
• Languages: English
• ISSNs: 1544-0478

Abstract

ABSTRACT: Novel approaches have been implemented to fabricate wound dressings including electrospinning of hydrogels, and coating-based nonwoven hydrogels. In this study, only the coating technique was studied in order to fabricate wound dressing. For this purpose, nonwoven cotton fabrics were coated with layer-by-layer PNaA (poly sodium acrylate) and poly 2-Acrylamido-2-methylpropane sulfonic acid (PAMPS). Microwave techniques were then implemented to create an antibacterial activity using cetyltrimethylammonium bromide (CTAB). For the characterization, the physical, mechanical and antibacterial properties of the different samples and to determine potential wound dressing candidates, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), swelling, and water vapor permeability (WVP) tests as well as contact angle measurements with water were performed. The application of microwave techniques using CTAB on the fabricated nonwoven-based wound dressings showed potential results of creating an efficient antibacterial activity with high fibroblast cell viability. The in vitro aspirin release experiment confirmed that the release amount depended on the number of hydrogel layers. The results of physical and mechanical tests showed that coated nonwoven with layers of hydrogels had the desired strength along breathability, flexibility, and wettability. These cumulative results indicate that the fabricated structures in this work are good potential candidates for wound dressing applications.