Diverse limbic comorbidities cause limbic and temporal atrophy in lewy body disease. (December 2022)

• Record Type: Journal Article
• Authors: Sakurai, Keita; Kaneda, Daita; Morimoto, Satoru; Uchida, Yuto; Inui, Shohei; Kimura, Yasuyuki; Cai, Chang; Kato, Takashi; Ito, Kengo; Hashizume, Yoshio
• Is Part Of: Parkinsonism & related disorders. Volume 105(2022)
• Page Start: 52
• Page End: 57
• Publication Date: 2022-12
• Subjects: Argyrophilic grain disease -- Comorbidity -- Lewy body disease -- Limbic-predominant age-related TDP-43 encephalopathy -- TDP-43 proteinopathy -- Voxel-based morphometry; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2022.11.001
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Background: In contrast to Alzheimer's disease (AD)-related pathology, the influence of comorbid limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) or argyrophilic grains (AG) on structural imaging in Lewy body disease (LBD) has seldom been evaluated. Objective: This study aimed to investigate whether non-AD limbic comorbidities, including LATE-NC and AG, cause cortical atrophy in LBD. Methods: Seventeen patients with pathologically confirmed LBD with lower Braak neurofibrillary tangle stage (<IV) and 10 healthy controls (HC) were included. Based on the presence of comorbid LATE-NC or AG, LBD patients were subdivided into nine patients with these proteinopathies (mixed LBD [mLBD]) and eight without (pure LBD [pLBD]). In addition to clinical feature evaluation, gray matter atrophy on voxel-based morphometry was compared between the two LBD and HC groups. Results: The mean age at antemortem magnetic resonance imaging of the mLBD patients was higher than that of the pLBD patients (84.3 ± 3.9 vs. 76.5 ± 10.5; p = .046). Irrespective of the presence or absence of comorbid LATE-NC or AG, all patients were clinically diagnosed with probable dementia with Lewy bodies or Parkinson's disease with dementia, respectively. Compared to the pLBD group, the mLBD group showed more conspicuous cortical atrophy of the bilateral hippocampus, amygdala, and temporal pole. Conclusions: Non-AD limbic comorbidities, including LATE-NC and AG, are associated with limbic and temporal atrophy in older patients with LBD. Therefore, the possibility of non-AD limbic comorbidities should be considered in the diagnosis of elderly patients with dementia with clinical symptoms of LBD and medial temporal atrophy. Highlights: Lewy body disease often coexists with non-Alzheimer's pathology in elderly patients. Comorbid non-Alzheimer's pathology can cause temporal atrophy in Lewy body disease. Possibility of comorbidities should be considered in Lewy body disease with atrophy.