Novel antibacterial dental resin containing silanized hydroxyapatite nanofibers with remineralization capability. Issue 12 (December 2022)

• Record Type: Journal Article
• Authors: Qin, Ludan; Yao, Shuo; Meng, Wenqing; Zhang, Jiajia; Shi, Ruirui; Zhou, Chuanjian; Wu, Junling
• Is Part Of: Dental materials. Volume 38:Issue 12(2022)
• Page Start: 1989
• Page End: 2002
• Publication Date: 2022-12
• Subjects: Hydroxyapatite nanofibers -- Silanization -- Erythromycin -- Resin -- Mechanical property -- Antibacterial -- Remineralization; Dentistry -- Periodicals; Dental materials -- Periodicals; 617.695
• DOI: 10.1016/j.dental.2022.11.014
• Languages: English
• ISSNs: 0109-5641

Abstract

Abstract: Objectives: Secondary caries is the primary issue that causes restoration failure. The objectives of this study were to: (1) synthesize silanized hydroxyapatite nanofibers loaded with erythromycin (s-HAFs@EM); (2) evaluate the mechanical property, antibacterial activity, and remineralization capability of the novel dental resin containing s-HAFs@EM. Methods: s-HAFs were prepared by the solvothermal approach and loaded with EM. Characterization and antibacterial activity were evaluated. Subsequently, s-HAFs@EM were incorporated into dental resin at different mass fractions (5 %, 10 %, 15 %, and 20 %), and then they were submitted to characterization, including mechanical property, antibacterial activity, remineralization capability, and cytotoxicity. Results: s-HAFs@EM were successfully synthesized, and they exhibited excellent antibacterial activity. Resin containing 15 % s-HAFs@EM exhibited the best flexural strength (118.67 ± 15.71 MPa) and elastic modulus (2.02 ± 0.30 GPa) (P < 0.05), which were increased by 65.43 % and 90.7 %, compared to those of neat resin, respectively. Resin with 15–20 % s-HAFs@EM showed high antibacterial rate (>85 %) when compared control group (P < 0.05). Furthermore, resin also exhibited a definite remineralization capability and good biosafety in vitro . Significance: This novel multifunctional resin with improved mechanical property, desirable antibacterial activity and remineralization capability is promising to combat secondary caries. Graphical Abstract: ga1 Highlights: Silanized hydroxyapatite nanofibers loaded with erythromycin (s-HAFs@EM) show excellent antibacterial activity. Resin contained with s-HAFs@EM presented mechanical property, antibacterial activity, and remineralization capability. This new multifunctional dental resin is a promising material to inhibit recurrent caries and restore the minerals.