Iridoids and sesquiterpenoids from Valeriana officinalis and their bioactivities. (January 2023)

• Record Type: Journal Article
• Authors: Shi, Dao-Qun; Liu, Jia-Jin; Feng, Yu-Mei; Zhou, Yan; Liao, Cai-Cen; Liu, Dan; Li, Rong-Tao; Li, Hong-Mei
• Is Part Of: Phytochemistry. Volume 205(2023)
• Publication Date: 2023-01
• Subjects: Valeriana officinalis -- Caprifoliaceae -- Iridoids -- Sesquiterpenoids -- Anti-inflammatory -- Anti-influenza virus; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113478
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Twenty-six iridoids, including six undescribed ones (iridoidvols A−F) and an undescribed natural one, along with ten known sesquiterpenoids were isolated from the roots and rhizomes of Valeriana officinalis . Structurally, iridoidvol A is the first example of iridoid with sesquiterpenoid acid ester. In addition, all of the isolates were evaluated for anti-inflammatory and anti-influenza virus activities. Among them, isovaltrate isovaleroyloxyhydrin exhibited a significant inhibitory effect on NO production with an IC50 value of 19.00 μM. Graphical abstract: Image 1 Highlights: Six undescribed iridoids were isolated from Valeriana officinalis . Iridoidvol A was the first example of iridoid with sesquiterpenoid acid ester. Isovaltrate isovaleroyloxyhydrin showed obvious anti-inflammatory activity.