A photosensitive sustainable lignin nanoplatform for multimodal image-guided mitochondria-targeted photodynamic and photothermal therapy. (December 2022)

• Record Type: Journal Article
• Authors: Liu, X.; Li, M.; Li, X.; Ge, M.; Liu, S.; Li, S.; Li, J.; Ding, J.; Ragauskas, A.J.; Sun, W.; James, T.D.; Chen, Z.
• Is Part Of: Materials today chemistry. Volume 26(2022)
• Publication Date: 2022-12
• Subjects: Photosensitive lignin nanoplatform -- reactive oxygen species -- Multimodal imaging -- Photodynamic and photothermal synergistic therapy; Chemistry -- Periodicals; Materials -- Research -- Periodicals; Materials science -- Periodicals; Chemistry; Materials -- Research; Electronic journals; Periodicals; 660.282
• DOI: 10.1016/j.mtchem.2022.101000
• Languages: English
• ISSNs: 2468-5194

Abstract

Abstract: Photoactivated nanocarriers exhibit significant potential for anticancer therapy, but complex design strategies, unsustainable substrates, and short wavelengths limit their practical application. Here, we designed a new lignin-derived photoactivated nanomaterial that exploits the sensitivity of the β - O -4 bond of lignin to singlet oxygen. This sustainable product was loaded with mitochondria-targeting chlorin e6 and black phosphorus quantum dots (BPQDs) to produce BPQDs@N-LgC NPs, which were used for mitochondria-targeted fluorescence/photoacoustic-guided photothermal and photodynamic therapy. When irradiated at 808 nm, the BPQDs in BPQDs@N-LgC NPs exhibited good photothermal conversion, which allowed photoacoustic imaging and inhibited tumor growth. When irradiated at 660 nm, the BPQDs@N-LgC NPs generated fluorescence and reactive oxygen species, which allowed photoluminescence imaging and further inhibited tumor growth. Cleavage of the β - O -4 bond of lignin by photo-triggered reactive oxygen species degraded the NPs and released the BPQDs, facilitating rapid excretion of the therapeutic nanomaterials. Our rationally designed BPQDs@N-LgC NPs exhibited good therapeutic efficacy, both in vitro and in vivo . Graphical abstract: Image 1 Highlights: N-LgC was established as a light-sensitive lignin platform for phototherapy. N-LgC capable of mitochondria-targeting multi-modal imaging. N-LgC facilitates multifunctional photodynamic and photothermal therapy.