Recent progress in biomedical and biotechnological applications of lignin-based spherical nano- and microstructures: a comprehensive review. (December 2022)

• Record Type: Journal Article
• Authors: Stanisz, M.; Klapiszewski, Ł.; Collins, M.N.; Jesionowski, T.
• Is Part Of: Materials today chemistry. Volume 26(2022)
• Publication Date: 2022-12
• Subjects: Lignin nano- and microstructures -- Spherical particles -- Drug delivery systems -- Antimicrobial properties -- 'Green' synthesis of materials; AAL-g-PMAA acryloyl alkali lignin-g-polymethacrylate copolymer -- AL-His/HCPT NP aminated lignin-histidine conjugate and 10-hydroxycamptothecin nanoparticles -- APG alkyl polyglycoside -- API active pharmaceutical ingredient -- ASLK-Chol acetone soluble fraction kraft lignin and cholesterol particles -- AVM avermectin -- BT 4-bromothymol -- CCM curcumin -- DBT 2, 4-dibromothymol -- DDIs drug–drug interactions -- DDS drug delivery systems -- DMAEMA 2-(dimethylamino)ethyl methacrylate -- DOX doxorubicin hydrochloride -- DTX docetaxel -- EHL/COS-x enzymatic hydrolysis lignin/chitosan oligosaccharide nanoparticles -- ENFLX enrofloxacin -- FA folic acid -- FA-MLHNPs folic-magnetic-functionalized lignin hollow nanoparticles -- GBM glioblastoma multiforme brain cancer -- HCPT 10-hydroxycamptomectin -- HIPEs high internal phase emulsions -- HIPPEs high internal phase Pickering emulsions -- HNK honokiol -- LBL layer-by-layer -- Lig/Chi NPs lignin/chitosan nanoparticles -- LMSs lignin microspheres -- LN lignin-based nanospheres -- MBT methylated bromothymol -- MDBT methylated dibromothymol -- MDR multidrug-resistant bacteria -- MT methylated thymol -- NIPAM N-isopropylacrylamide -- PCMs phase change microcapsules -- PDT photodynamic therapy -- PEG poly(ethylene glycol) -- PEGDGE glycol diglycidyl ether -- PLGA poly(lactic-co-glycolic) acid -- P-LHNPs 1-pyrenebutyric acid grafted lignin hollow nanoparticles -- PLLA poly-l-lactide -- QC quinacrine -- SLS-MCs softwood lignosulfonate-based microcapsules -- THPP 5, 10, 15, 20-tetrakis(4-hydroxyphenyl)-21H, 23H-porphyrin -- VPA valproic acid -- YHV yellow head virus; Chemistry -- Periodicals; Materials -- Research -- Periodicals; Materials science -- Periodicals; Chemistry; Materials -- Research; Electronic journals; Periodicals; 660.282
• DOI: 10.1016/j.mtchem.2022.101198
• Languages: English
• ISSNs: 2468-5194

Abstract

Abstract: Spherical particles based on materials of natural origin have recently gained increased attention because of their unique properties, including shape, structure, and ability to combine with other materials. Lignin has potential to be applied across multiple sectors, with recent focus on its valorization in high end application routes which favor its renewability, biocompatibility, and non-toxicity. The most promising findings are reported, that spherical lignin particles are a very effective carrier and delivery vehicle for active pharmaceutical ingredients for the treatment of various diseases, including cancers etc. Due to recent developments, lignin can be successfully used for accelerated wound healing and for growth inhibition against a variety of bacterial strains taking advantage of its inherent antimicrobial and antioxidant properties. Notably, lignin particles are also finding opportunities in the agrochemical industry, taking advantage of a combination of properties such as high stability, composability, and the possibility of encapsulation of pesticides and fungicides without increased pollution of the environment. The presented review aims to discuss the impact of recent developments related to lignin-based spherical particles on novel biomedical and biotechnological application, which may provide guidance for future possibilities for the valorization of lignin. Graphical abstract: Image 1 Highlights: Novel trends using spherical lignin particles in biomedical and biotechnological applications. Elucidation of structure/property relationships of lignin particles. Lignin particles for micro- and nanosized drug delivery systems. Spherical lignin stabilizes high internal phase Pickering emulsions. Lignin particles as delivery vehicles for pesticides, fungicides and hormones for plants.