Nonordered dendritic mesoporous silica nanoparticles as promising platforms for advanced methods of diagnosis and therapies. (December 2022)

• Record Type: Journal Article
• Authors: Malekmohammadi, S.; Mohammed, R.U.R.; Samadian, H.; Zarebkohan, A.; García-Fernández, A.; Kokil, G.R.; Sharifi, F.; Esmaeili, J.; Bhia, M.; Razavi, M.; Bodaghi, M.; Kumeria, T.; Martínez-Máñez, R.
• Is Part Of: Materials today chemistry. Volume 26(2022)
• Publication Date: 2022-12
• Subjects: Dendritic Mesoporous Silica Nanoparticles -- Drug delivery -- Biomolecules -- Therapy -- Diagnostic; Chemistry -- Periodicals; Materials -- Research -- Periodicals; Materials science -- Periodicals; Chemistry; Materials -- Research; Electronic journals; Periodicals; 660.282
• DOI: 10.1016/j.mtchem.2022.101144
• Languages: English
• ISSNs: 2468-5194

Abstract

Abstract: Dendritic mesoporous silica nanoparticles (DMSNs) are a new generation of porous materials that have gained great attention compared to other mesoporous silicas due to attractive properties, including straightforward synthesis methods, modular surface chemistry, high surface area, tunable pore size, chemical inertness, particle size distribution, excellent biocompatibility, biodegradability, and high pore volume compared with conventional mesoporous materials. The last years have witnessed a blooming growth of the extensive utilization of DMSNs as an efficient platform in a broad spectrum of biomedical and industrial applications, such as catalysis, energy harvesting, biosensing, drug/gene delivery, imaging, theranostics, and tissue engineering. DMSNs are considered great candidates for nanomedicine applications due to their ease of surface functionalization for targeted and controlled therapeutic delivery, high therapeutic loading capacity, minimizing adverse effects, and enhancing biocompatibility. In this review, we will extensively detail state-of-the-art studies on recent advances in synthesis methods, structure, properties, and applications of DMSNs in the biomedical field with an emphasis on the different delivery routes, cargos, and targeting approaches and a wide range of therapeutic, diagnostic, tissue engineering, vaccination applications and challenges and future implications of DMSNs as cutting-edge technology in medicine. Graphical abstract: Image 1 Highlights: The review displays the potential of dendritic mesoporous silica nanoparticles (DMSNs) in different biomedical applications. DMSNs are presented as next-generation multifunctional porous nanocarrier. The large pore structure of DMSNs allows the encapsulation of a wide range of payloads and allows diverse functionalities. The better degradability of DMSNs is a crucial factor in the safety of cutting-edge technology in medicine.