Effect of electrolytes on the sol–gel phase transitions in a Pluronic F127/carboxymethyl cellulose aqueous system: Phase map, rheology and NMR self-diffusion study. (5th December 2022)

• Record Type: Journal Article
• Authors: Monduzzi, Maura; Musu, Giulia; Grosso, Massimiliano; Carucci, Cristina; Lindman, Björn; Söderman, Olle; Salis, Andrea
• Is Part Of: European polymer journal. Volume 181(2022)
• Publication Date: 2022-12-05
• Subjects: Pluronic F127 -- NaCMC -- Electrolytes -- Thermoresponsive hydrogels; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2022.111707
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: Pluronic F127, NaCMC, and NaCl provide a thermoresponsive platform suitable for drug-delivery. Complex viscosity decreases with increasing salt concentration. Hofmeister effects are highlighted by complex viscosity. Salt addition decreases crowding effect of NaCMC on F127. PGSE NMR highlights F127 polydispersity. Abstract: This investigation aims to obtain a thermosensitive platform useful for specific nanomedicine applications through the addition of suitable salts. An aqueous mixture consisting of the copolymer Pluronic F127 and sodium carboxymethyl-cellulose, in a ratio of 20/4 by weight, in the presence of different concentrations of Na2 SO4, NaCl, and NaSCN, was investigated using the visual inversion tube approach to estimate a phase map, and then characterized through rheological measurements. The formation of a cubic liquid crystalline phase at temperatures higher than 37 °C was suggested in all systems. The complex viscosity, decreases in the presence of salts in the order Na2 SO4 > NaCl > NaSCN with more marked effect for lower concentrations. Salt addition allows to tune the crowding effect of NaCMC. For the polymer mixture and for a sample containing NaCl, 1 H NMR self-diffusion experiments display a non-mono-exponential decay of the echo signals of Pluronic F127, caused by the polydispersity of commercial Pluronic F127. The rheological properties along with the diffusion behaviour of the liquid crystal micelles suggest that a sample containing NaCl 0.07 mol/kg, with a sol-hard gel transition temperature around 35 °C, close to that of the body, may be a suitable and biocompatible thermosensitive platform to administer both hydrophobic and hydrophilic drugs such as antibiotics, anticancer drugs or growing factors. Synopsis: A simple thermoresponsive platform for drug delivery: Pluronic F127, NaCMC and NaCl.