Early‐ and late‐onset postpartum depression exhibit distinct associated factors: the IGEDEPP prospective cohort study. (6th April 2021)

• Record Type: Journal Article
• Authors: Tebeka, S; Le Strat, Y; Mandelbrot, L; Benachi, A; Dommergues, M; Kayem, G; Lepercq, J; Luton, D; Ville, Y; Ramoz, N; Mullaert, J; Dubertret, C
• Other Names: Bertin Emmanuelle investigator.; Bourneuf Cecile investigator.; Colombe Jeanne investigator.; Couppa Laura investigator.; Georges Fanny investigator.; Hebbache Celine investigator.; Le Bars Marie investigator.; Madhavi Julie Guiot investigator.; Parent Cindy investigator.; de Premorel Alix investigator.
• Is Part Of: BJOG. Volume 128:Number 10(2021)
• Page Start: 1683
• Page End: 1693
• Publication Date: 2021-04-06
• Subjects: Childhood trauma -- depression -- postpartum -- psychiatric history -- stressful life events; Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.16688
• Languages: English
• ISSNs: 1470-0328

Abstract

Abstract : Objective: To identify risk factors for early‐ and late‐onset postpartum depression (PPD) among a wide range of variables, including sociodemographic characteristics, childhood trauma, stressful life events during pregnancy and history of personal and family psychiatric disorders, and to assess the contribution of each risk factor. Design: Nested case–control study in a prospective longitudinal cohort study. Setting: Eight maternity departments in the Paris metropolitan area, France. Sample: A cohort of 3310 women with deliveries between November 2011 and June 2016. Methods: Cases were women with early‐ or late‐onset PPD. Controls were women without depression during pregnancy or the postpartum period. Logistic regression adjusted on sociodemographic variables was performed for each outcome and a multivariable model was proposed based on a stepwise selection procedure. Main outcome measures: Early‐ and late‐onset PPD assessed at 2 months and 1 year postpartum, respectively. Results: Stressful life events during pregnancy have a dose–response relationship with both early‐ and late‐onset PPD. Conclusions: Early‐ and late‐onset PPD presented distinct patterns of determinants. These results have important consequences in terms of prevention and specific care. Tweetable abstract: Early‐ and late‐onset postpartum depression are associated with stressful life events and psychiatric history. Tweetable abstract: Early‐ and late‐onset postpartum depression are associated with stressful life events and psychiatric history.