Inside Back Cover: Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria (Angew. Chem. Int. Ed. 37/2019). Issue 37 (23rd August 2019)

• Record Type: Journal Article
• Authors: Çapcı, Aysun; Lorion, Mélanie M.; Wang, Hui; Simon, Nina; Leidenberger, Maria; Borges Silva, Mariana C.; Moreira, Diogo R. M.; Zhu, Yongping; Meng, Yuqing; Chen, Jia Yun; Lee, Yew Mun; Friedrich, Oliver; Kappes, Barbara; Wang, Jigang; Ackermann, Lutz; Tsogoeva, Svetlana B.
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 37(2019)
• Page Start: 13161
• Page End: 13161
• Publication Date: 2019-08-23
• Subjects: antimalarial agents -- artemisinin -- drug resistance -- hybridization -- proteomics; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201910149
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Overcoming drug resistance in malaria parasites against available drugs is possible by using drug hybrids, as reported by S. B. Tsogoeva, L. Ackermann, J. Wang, and co‐workers in their Research Article on page 13066 ff. The merging of two differently acting drugs (e.g., artemisinin and chloroquine) in one hybrid compound gives simultaneous cellular uptake of the pharmacophore components of the hybrid, and dual action is achieved, thereby enabling novel functions targeting pathogens, multidrug resistance.