Cover Picture: Conditional Singlet Oxygen Generation through a Bioorthogonal DNA‐targeted Tetrazine Reaction (Angew. Chem. Int. Ed. 37/2019). Issue 37 (23rd August 2019)

• Record Type: Journal Article
• Authors: Linden, Greta; Zhang, Lei; Pieck, Fabian; Linne, Uwe; Kosenkov, Dmitri; Tonner, Ralf; Vázquez, Olalla
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 37(2019)
• Page Start: 12719
• Page End: 12719
• Publication Date: 2019-08-23
• Subjects: bioorthogonal reactions -- BODIPY dyes -- photodynamic therapy -- singlet oxygen -- tetrazine; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201909198
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Tetrazine can act as an effective singlet oxygen quencher of halogenated BODIPY photosensitizers. In their Communication on page 12868 ff., O. Vázquez and co‐workers report bioorthogonal, activatable probes that allow both organelle‐specific localization and conditional singlet oxygen production simultaneously. These compounds open new avenues to combat the current limitations of photodynamic therapy. Cover design: Prof. M. Eugenio Vázquez.