Evaluation of Gibbilimbol B, Isolated from Piper malacophyllum (Piperaceae), as an Antischistosomal Agent. Issue 10 (29th September 2021)

• Record Type: Journal Article
• Authors: Carnaúba, Paulo U.; Mengarda, Ana C.; Rodrigues, Vinícius C.; Morais, Thiago R.; de Oliveira, Alberto; Lago, João Henrique G.; de Moraes, Josué
• Is Part Of: Chemistry & biodiversity. Volume 18:Issue 10(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-29
• Subjects: schistosomiasis -- neglected tropical diseases -- natural product -- schistosomicidal activity -- antischistosomal compound; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202100503
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Infections caused by parasitic worms impose a considerable worldwide health burden. One of the most impactful is schistosomiasis, a disease caused by blood‐dwelling of the genus Schistosoma that affects more than 230 million people worldwide. Since praziquantel has also been extensively used to treat schistosomiasis and other parasitic flatworm infections, there is an urgent need to identify novel anthelmintic compounds, mainly from natural sources. In this study, the hexane extract from roots of Piper malacophyllum (Piperaceae) showed to be mainly composed for gibbilimbol B by HPLC/ESI‐HRMS. Based on this result, this compound was isolated by chromatographic steps and its structure was confirmed by NMR. In vitro bioassays showed that gibbilimbol B was more active than praziquantel against larval stage of S. mansoni, with effective concentrations of 50 % (EC50 ) and 90 % (EC90 ) values of 2.6 and 3.4 μM, respectively. Importantly, gibbilimbol B showed no cytotoxicity to mammalian cells at a concentration 190 times greater than the antiparasitic effect, giving support for the anthelmintic potential of gibbilimbol B as lead compound for novel antischistosomal agents. Abstract :