Blood CD9+ B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation. Issue 11 (21st August 2019)

• Record Type: Journal Article
• Authors: Brosseau, Carole; Danger, Richard; Durand, Maxim; Durand, Eugénie; Foureau, Aurore; Lacoste, Philippe; Tissot, Adrien; Roux, Antoine; Reynaud‐Gaubert, Martine; Kessler, Romain; Mussot, Sacha; Dromer, Claire; Brugière, Olivier; Mornex, Jean François; Guillemain, Romain; Claustre, Johanna; Magnan, Antoine; Brouard, Sophie
• Other Names: Jougon J. investigator.; Velly J.‐F. investigator.; Rozé H. investigator.; Blanchard E. investigator.; Antoine M. investigator.; Cappello M. investigator.; Ruiz M. investigator.; Sokolow Y. investigator.; Vanden Eynden F investigator.; Van Nooten G. investigator.; Barvais L. investigator.; Berré J. investigator.; Brimioulle S. investigator.; De Backer D. investigator.; Créteur J. investigator.; Engelman E investigator.; Huybrechts I. investigator.; Ickx B. investigator.; Preiser T.J.C. investigator.; Tuna T. investigator.; Van Obberghe L. investigator.; Vancutsem N. investigator.; Vincent J.‐L. investigator.; De Vuyst P. investigator.; Etienne I. investigator.; Féry F. investigator.; Jacobs F. investigator.; Knoop C. investigator.; Vachiéry J.L. investigator.; Van den Borne P. investigator.; Wellemans I. investigator.; Amand G. investigator.; Collignon L. investigator.; Giroux M. investigator.; Angelescu D. investigator.; Chavanon O. investigator.; Hacini R. investigator.; Martin C. investigator.; Pirvu A. investigator.; Porcu P. investigator.; Albaladejo P. investigator.; Allègre C. investigator.; Bataillard A. investigator.; Bedague D. investigator.; Briot E. investigator.; Casez‐Brasseur M. investigator.; Colas D. investigator.; Dessertaine G. investigator.; Francony G. investigator.; Hebrard A. investigator.; Marino M.R. investigator.; Protar D. investigator.; Rehm D. investigator.; Robin S investigator.; Rossi‐Blancher M. investigator.; Augier C. investigator.; Bedouch P. investigator.; Boignard A. investigator.; Bouvaist H. investigator.; Briault A. investigator.; Camara B. investigator.; Chanoine S. investigator.; Dubuc M. investigator.; Quétant S. investigator.; Maurizi J. investigator.; Pavèse P. investigator.; Pison C. investigator.; Saint‐Raymond C. investigator.; Wion N. investigator.; Chérion C. investigator.; Grima R. investigator.; Jegaden O. investigator.; Maury J.‐M. investigator.; Tronc F. investigator.; Flamens C. investigator.; Paulus S. investigator.; Philit F. investigator.; Senechal A. investigator.; Glérant J.‐C. investigator.; Turquier S. investigator.; Gamondes D. investigator.; Chalabresse L. investigator.; Thivolet‐Bejui F. investigator.; Barnel C. investigator.; Dubois C. investigator.; Tiberghien A. investigator.; Pimpec‐Barthes F. investigator.; Bel A. investigator.; Mordant P. investigator.; Achouh P. investigator.; Boussaud V. investigator.; Méléard D. investigator.; Bricourt M.O. investigator.; Cholley B. investigator.; Pezella V. investigator.; Brioude G. investigator.; D'Journo X.B. investigator.; Doddoli C. investigator.; Thomas P. investigator.; Trousse D. investigator.; Dizier S. investigator.; Leone M. investigator.; Papazian L. investigator.; Bregeon F. investigator.; Coltey B. investigator.; Dufeu N. investigator.; Dutau H. investigator.; Garcia S. investigator.; Gaubert J.Y. investigator.; Gomez C. investigator.; Laroumagne S. investigator.; Mouton G. investigator.; Nieves A. investigator.; Picard Ch. investigator.; Rolain J.M. investigator.; Sampol E. investigator.; Secq V. investigator.; Perigaud C. investigator.; Roussel J.C. investigator.; Senage T. investigator.; Mugniot A. investigator.; Danner I. investigator.; Haloun A. investigator.; Abbes S. investigator.; Bry C. investigator.; Blanc F.X. investigator.; Lepoivre T. investigator.; Botturi‐Cavaillès K. investigator.; Loy J. investigator.; Bernard M. investigator.; Godard E. investigator.; Royer P.‐J. investigator.; Henrio K. investigator.; Dartevelle Ph. investigator.; Fabre D. investigator.; Fadel E. investigator.; Mercier O. investigator.; Stephan F. investigator.; Viard P. investigator.; Cerrina J. investigator.; Dorfmuller P. investigator.; Feuillet S. investigator.; Ghigna M. investigator.; Hervén Ph. investigator.; Le Roy Ladurie F. investigator.; Le Pavec J. investigator.; Thomas de Montpreville V. investigator.; Lamrani L. investigator.; Castier Y. investigator.; Mordant P. investigator.; Cerceau P. investigator.; Augustin P. investigator.; Jean‐Baptiste S. investigator.; Boudinet S. investigator.; Montravers P. investigator.; Dauriat G. investigator.; Jébrak G. investigator.; Mal H. investigator.; Marceau A. investigator.; Métivier A.‐C. investigator.; Thabut G. investigator.; Lhuillier E. investigator.; Dupin C. investigator.; Bunel V. investigator.; Falcoz P. investigator.; Massard G. investigator.; Santelmo N. investigator.; Ajob G. investigator.; Collange O. investigator.; Helms O. investigator.; Hentz J. investigator.; Roche A. investigator.; Bakouboula B. investigator.; Degot T. investigator.; Dory A. investigator.; Hirschi S. investigator.; Ohlmann‐Caillard S. investigator.; Kessler L. investigator.; Schuller A. investigator.; Bennedif K. investigator.; Vargas S. investigator.; Bonnette P. investigator.; Chapelier A. investigator.; Puyo P. investigator.; Sage E. investigator.; Bresson J. investigator.; Caille V. investigator.; Cerf C. investigator.; Devaquet J. investigator.; Dumans‐Nizard V. investigator.; Felten M.L. investigator.; Fischler M. investigator.; Si Larbi A.G. investigator.; Leguen M. investigator.; Ley L. investigator.; Liu N. investigator.; Trebbia G. investigator.; De Miranda S. investigator.; Douvry B. investigator.; Gonin F. investigator.; Grenet D. investigator.; Hamid A.M. investigator.; Neveu H. investigator.; Parquin F. investigator.; Picard C. investigator.; Stern M. investigator.; Bouillioud F. investigator.; Cahen P. investigator.; Colombat M. investigator.; Dautricourt C. investigator.; Delahousse M. investigator.; D'Urso B. investigator.; Gravisse J. investigator.; Guth A. investigator.; Hillaire S. investigator.; Honderlick P. investigator.; Lequintrec M. investigator.; Longchampt E. investigator.; Mellot F. investigator.; Scherrer A. investigator.; Temagoult L. investigator.; Tricot L. investigator.; Vasse M. investigator.; Veyrie C. investigator.; Zemoura L. investigator.; Dahan M. investigator.; Murris M. investigator.; Benahoua H. investigator.; Berjaud J. investigator.; Le Borgne Krams A. investigator.; Crognier L. investigator.; Brouchet L. investigator.; Mathe O. investigator.; Didier A. investigator.; Krueger T. investigator.; Ris H.B. investigator.; Gonzalez M. investigator.; Aubert J.‐D. investigator.; Nicod L.P. investigator.; Marsland B.J. investigator.; Berutto T.C. investigator.; Rochat T. investigator.; Soccal P. investigator.; Jolliet Ph. investigator.; Koutsokera A. investigator.; Marcucci C. investigator.; Manuel O. investigator.; Bernasconi E. investigator.; Chollet M. investigator.; Gronchi F. investigator.; Courbon C. investigator.; Hillinger S. investigator.; Inci I. investigator.; Kestenholz P. investigator.; Weder W. investigator.; Schuepbach R. investigator.; Zalunardo M. investigator.; Benden C. investigator.; Buergi U. investigator.; Huber L.C. investigator.; Isenring B. investigator.; Schuurmans M.M. investigator.; Gaspert A. investigator.; Holzmann D. investigator.; Müller N. investigator.; Schmid C. investigator.; Vrugt B. investigator.; Rechsteiner T. investigator.; Fritz A. investigator.; Maier D. investigator.; Deplanche K. investigator.; Koubi D. investigator.; Ernst F. investigator.; Paprotka T. investigator.; Schmitt M. investigator.; Wahl B. investigator.; Boissel J.‐P. investigator.; Olivera‐Botello G. investigator.; Trocmé C. investigator.; Toussaint B. investigator.; Bourgoin‐Voillard S. investigator.; Séve M. investigator.; Benmerad M. investigator.; Siroux V. investigator.; Slama R. investigator.; Auffray C. investigator.; Charron D. investigator.; Lefaudeux D. investigator.; Pellet J. investigator.;
• Is Part Of: American journal of transplantation. Volume 19:Issue 11(2019)
• Page Start: 3162
• Page End: 3175
• Publication Date: 2019-08-21
• Subjects: B cell biology -- basic (laboratory) research/science -- biomarker -- bronchiolitis obliterans (BOS) -- lung transplantation/pulmonology -- translational research/science; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.15532
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : Bronchiolitis obliterans syndrome is the main limitation for long‐term survival after lung transplantation. Some specific B cell populations are associated with long‐term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow‐up. CD24 hi CD38 hi transitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24 hi CD38 hi transitional B cells specifically secrete IL‐10 and express CD9. Thus, patients with a total CD9 + B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL‐10‐secreting CD24 hi CD38 hi transitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9‐expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long‐term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival. Abstract : In lung transplant patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow‐up, IL‐10–secreting CD24hiCD38hi transitional B cells expressing CD9 are associated with better allograft outcome, suggesting CD9‐expressing B cells as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival.