Alpha‐Synuclein RT‐QuIC in Idiopathic Normal Pressure Hydrocephalus. Issue 6 (28th September 2022)

• Record Type: Journal Article
• Authors: Fasano, Alfonso; Martinez‐Valbuena, Ivan; Azevedo, Paula; da Silva, Carolina Candeias; Algarni, Musleh; Vasilevskaya, Anna; Anastassiadis, Chloe; Taghdiri, Foad; Kongkham, Paul; Radovanovic, Ivan; Zadeh, Gelareh; Lang, Anthony E.; Tang‐Wai, David F.; Kovacs, Gabor G.; Tartaglia, Maria Carmela
• Is Part Of: Annals of neurology. Volume 92:Issue 6(2022)
• Page Start: 985
• Page End: 991
• Publication Date: 2022-09-28
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.26505
• Languages: English
• ISSNs: 0364-5134

Abstract

Abstract : This study quantified the occurrence of an underlying synucleinopathy in 50 patients with idiopathic normal pressure hydrocephalus by means of real‐time quaking‐induced conversion, a highly sensitive and specific technique capable of detecting and amplifying misfolded aggregated forms of α‐synuclein in the cerebrospinal fluid. Seven patients were positive and they did not differ from negative cases, except for a more frequent L‐dopa responsiveness and gait characterized by a wider base. The two groups did not differ in terms of response rate to tap test or shunt surgery, although step length and gait velocity improved by a lesser extent in positive cases. ANN NEUROL 2022;92:985–991