Cancer stem cell theory: Are we moving past the mist?. Issue 11 (November 2019)

• Record Type: Journal Article
• Authors: Hung, Kai-Feng; Yang, Ting; Kao, Shou-Yen
• Is Part Of: Journal of the Chinese Medical Association. Volume 82:Issue 11(2019)
• Page Start: 814
• Page End: 818
• Publication Date: 2019-11
• Subjects: Autophagy -- Cancer stem cells -- Cellular stress -- Epithelial–mesenchymal transition -- Heterogenicity -- Plasticity; Medicine -- Periodicals; 610.5
• DOI: 10.1097/JCMA.0000000000000186
• Languages: English
• ISSNs: 1726-4901

Abstract

Abstract : Cancer stem cells (CSC) are a subpopulation of tumor cells that have superior capacities of self-renewal, metastatic dissemination, and chemoresistance. These characteristics resemble, to some extent, the outcome of certain biological processes, including epithelial–mesenchymal transition (EMT), autophagy, and cellular stress response. Indeed, it has been shown that the stimuli that induce these processes and CSC are overlapping, and CSC and tumor cells that underwent EMT or autophagy are much alike. However, as the cross talk between CSC, EMT, autophagy, and cellular stress is further explored, these processes are also found to have an opposing role in CSC, depending on the condition and status of cells. This contextual effect is likely due to overwhelming reliance on CSC markers for their identification, and/or discrepancies in recognition of CSC as a particular cell population or cellular state. In this review, we summarize how EMT, autophagy, and cellular stress response are tied or unwound with CSC. We also discuss the current view of CSC theory evolved from the emphasis of heterogenicity and plasticity of CSC.