Recent Advances in the Asymmetric Total Synthesis of Camptothecin. Issue 11 (10th October 2022)

• Record Type: Journal Article
• Authors: Song, Liangliang; Lv, Zhenwei; Zhang, Kui; Wu, Yile; Van der Eycken, Erik V.; Cai, Lingchao
• Is Part Of: Asian journal of organic chemistry. Volume 11:Issue 11(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-10
• Subjects: total synthesis -- asymmetric catalysis -- camptothecin -- alkaloids -- natural product; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202200515
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: During the past decades, a variety of routes for the total synthesis of camptothecin have been reported. Considering only ( S )‐camptothecin and ( S )‐camptothecin analogues possessing the ability to inhibit DNA enzyme topoisomerase I, numerous advances have been achieved for the asymmetric total synthesis of camptothecin, providing concise and scalable approaches to ( S )‐camptothecin for the academic community and pharmaceutical industry. This review outlines recent advances in the asymmetric total synthesis of camptothecin, and is timely and highly desirable for the rapid development of this field. By constructing the chiral tertiary alcohol center, diverse attractive strategies have been developed for the total synthesis of ( S )‐camptothecin. Abstract : This review outlines recent advances in the asymmetric total synthesis of camptothecin and is timely and highly desirable for the rapid development of this field. By constructing the chiral tertiary alcohol center, diverse attractive strategies have been developed for the total synthesis of ( S )‐camptothecin.