Estrogen receptor α revised: Expression, structure, function, and stability. (3rd October 2022)

• Record Type: Journal Article
• Authors: Habara, Makoto; Shimada, Midori
• Is Part Of: BioEssays. Volume 44:Number 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-03
• Subjects: breast cancer -- calcineurin -- estrogen receptor α -- FKBP -- phosphorylation -- post‐translational modification -- ubiquitination; Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.202200148
• Languages: English
• ISSNs: 0265-9247

Abstract

Abstract: Estrogen receptor α (ERα) is a ligand‐dependent transcription factor that regulates the expression of estrogen‐responsive genes. Approximately 70% of patients with breast cancer are ERα positive. Estrogen stimulates cancer cell proliferation and contributes to tumor progression. Endocrine therapies, which suppress the ERα signaling pathway, significantly improve the prognosis of patients with breast cancer. However, the development of de novo or acquired endocrine therapy resistance remains a barrier to breast cancer treatment. Therefore, understanding the regulatory mechanisms of ERα is essential to overcome the resistance to treatment. This review focuses on the regulation of ERα expression, including copy number variation, epigenetic regulation, transcriptional regulation, and stability, as well as functions from the point of view post‐translational modifications. Abstract : Understanding the regulatory mechanisms of ERα is essential to overcome the breast cancer. This review focuses on the ERα expression, structure, stability, as well as functions from the point of view post‐transcriptional modifications.