The abundance of Ruminococcus bromii is associated with faecal butyrate levels and atopic dermatitis in infancy. Issue 12 (18th August 2022)

• Record Type: Journal Article
• Authors: Sasaki, Mari; Schwab, Clarissa; Ramirez Garcia, Alejandro; Li, Qing; Ferstl, Ruth; Bersuch, Eugen; Akdis, Cezmi A.; Lauener, Roger; Frei, Remo; Roduit, Caroline
• Other Names: Bieber Thomas investigator.; Schmid‐Grendelmeier Peter investigator.; Traidl‐Hoffmann Claudia investigator.; Brüggen Marie‐Charlotte investigator.; Rhyner Claudio investigator.
• Is Part Of: Allergy. Volume 77:Issue 12(2022)
• Page Start: 3629
• Page End: 3640
• Publication Date: 2022-08-18
• Subjects: atopic dermatitis -- butyrate -- microbiota -- resistant starch -- short‐chain fatty acid; Allergy -- Periodicals; 616.97
• DOI: 10.1111/all.15440
• Languages: English
• ISSNs: 0105-4538

Abstract

Abstract: Background: Impaired microbial development and decreased levels of short‐chain fatty acids, particularly butyrate, is suggested to have a role in the development of atopic dermatitis (AD). Methods: Faecal microbiota composition, abundance of selected bacterial groups and fermentation metabolites were compared at 90, 180 and 360 days of life between 27 children who developed AD by age one (AD group), and 39 controls (non‐AD group) among the CARE (Childhood AlleRgy, nutrition and Environment) study cohort. Results: Diversity within the Firmicutes and Bacteroidetes phyla in the faecal microbiota was lower in the AD group compared with the non‐AD group. Longitudinal analysis showed multiple amplicon sequence variants (ASV) within the same bacterial family to be differentially abundant. Namely, Ruminococcus bromii, a keystone primary starch degrader, and Akkermansia muciniphila, a mucin‐utilizer, had lower abundance among the AD group. Children with AD were less likely to have high levels of faecal butyrate at 360 days compared with those without AD (11.5% vs 34.2%). At 360 days, children with high abundance of R. bromii had higher level of butyrate as well as lower proportion of children with AD compared to children with low abundance of R. bromii (11.1–12.5% vs 44.4–52.5%), which was independent of the abundance of the major butyrate producers. Conclusion: Our results suggested that R. bromii and other primary degraders might play an important role in the differences in microbial cross‐feeding and metabolite formation between children with and without AD, which may influence the risk of developing the disease. Abstract : Children who developed atopic dermatitis (AD) in infancy were less likely to have high faecal butyrate levels at 1 year old, compared to children without AD. The abundance of Ruminococcus bromii, a keystone starch degrader, was lower in children who developed AD than in children without AD, while the abundance of major butyrate producers was similar. Abbreviations: AD, atopic dermatitis; CARE study, Childhood AlleRgy, nutrition and Environment study; R. bromii, Ruminococcus bromii