Effects of anti‐seizure therapies on sleep in patients with epilepsy: A literature review. (7th September 2022)

• Record Type: Journal Article
• Authors: Ye, Lingqi; Xu, Jiahui; Chen, Cong; Zhang, Lisan; Wang, Shuang
• Other Names: Wang Qun guestEditor.; Tao James guestEditor.
• Is Part Of: Acta neurologica Scandinavica. Volume 146:Number 6(2022)
• Page Start: 767
• Page End: 774
• Publication Date: 2022-09-07
• Subjects: anti‐seizure medication -- brain‐responsive neurostimulator -- deep brain stimulation -- epilepsy -- epilepsy surgery -- ketogenic diet -- sleep -- vagus nerve stimulation; Neurology -- Periodicals; 616.8
• DOI: 10.1111/ane.13699
• Languages: English
• ISSNs: 0001-6314

Abstract

Abstract : Sleep disorder is common in epilepsy. With a recent rapid development in sleep medicine, it has been increasingly recognized that anti‐seizure therapies, either anti‐seizure medications (ASMs) or non‐pharmaceutical approaches, can take direct or indirect influence on sleep in patients with epilepsy. Here, we systematically review the effect of anti‐seizure treatments on sleep. ASMs targeting at different sites exerted various effects on both sleep structure and sleep quality. Non‐pharmaceutical treatments including resective surgery, ketogenic diet, and transcranial magnetic stimulation appear to have a positive effect on sleep, while vagus nerve stimulation, deep brain stimulation, and brain‐responsive neurostimulation are likely to interrupt sleep and exacerbate sleep‐disordered breathing. The potential mechanisms underlying how non‐pharmacological approaches affect sleep are also discussed. The limitation of most studies is that they were largely based on small cohorts by short‐term observations. Further well‐designed and large‐scale investigations in this field are warranted. Understanding the effect of anti‐seizure therapies on sleep can guide clinicians to optimize epilepsy treatment in the future.