Supramolecular Assembly of Organoplatinum(II) Complexes for Subcellular Distribution and Cell Viability Monitoring with Differentiated Imaging. Issue 49 (28th October 2022)

• Record Type: Journal Article
• Authors: Li, Baoning; Wang, Yaping; Chan, Michael Ho‐Yeung; Pan, Mei; Li, Yonguang; Yam, Vivian Wing‐Wah
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 49(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-28
• Subjects: Bio-Imaging -- Luminescence -- Platinum(II) -- Self-Assembly -- Subcellular Distribution; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202210703
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The ability to precisely control the subcellular distribution of luminous materials presents unprecedented advantages for understanding cell biology and disease therapy. We introduce a luminescence tool for subcellular distribution imaging and differentiation of live and dead cells, utilizing cationic organoplatinum(II) complexes that exhibit well‐defined monomeric to aggregate nanostructures along with concentration‐dependent switchable luminescence from green to red due to assembly via Pt II ⋅⋅⋅Pt II and π–π stacking interactions. One of the complexes was chosen to demonstrate the unique lysosome‐to‐nucleus subcellular re‐distribution and imaging capability in live and dead cells, respectively, which represents the first example to discriminate the subcellular localization of platinum(II) complexes through differential luminescence response. These new findings facilitate the fundamental understanding of self‐assembly behaviors of platinum(II) complexes for potential subcellular detection assays. Abstract : The aggregation affinities of the platinum(II) complexes enable them to exhibit well‐defined monomeric to aggregate nanostructures along with concentration‐dependent switchable luminescence from green to red, attributed to the extent of Pt II ⋅⋅⋅Pt II and π–π stacking interactions. The platinum(II) complex is applied to manifest the unique lysosome‐to‐nucleus subcellular re‐distribution and imaging capability in live and dead cells.