Thromboembolism and bleeding in patients with autoimmune blistering disease. (23rd November 2022)

• Record Type: Journal Article
• Authors: Sho, Yuriko; Sakai, Takashi; Matsuda‐Hirose, Haruna; Yamate, Tomoko; Hatano, Yutaka
• Is Part Of: Clinical and experimental dermatology. Volume 47:Number 12(2022)
• Page Start: 2255
• Page End: 2260
• Publication Date: 2022-11-23
• Subjects: Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/ced.15375
• Languages: English
• ISSNs: 0307-6938

Abstract

Abstract: The prevention and early detection of venous thromboembolism (VTE), including pulmonary embolism (PE), is essential in daily medical practice. We previously reported the risk of VTE in patients with autoimmune blistering disease (AIBD). We have also experienced multiple cases of pemphigus or pemphigoid that developed severe complications related to abnormal blood coagulation other than VTE. This study summarizes and discusses those cases. Nine patients with AIBD developed thromboembolism and/or bleeding; these included (some patients overlapped) six patients with VTE, including five patients with PE; three patients with severe bleeding; one patient with sudden critical limb ischaemia resulting in thigh amputation; and one patient with cerebral infarction. Although five patients developed PE, only one had apparent respiratory symptoms with PE, and a second developed severe bleeding during the treatment for PE. Clinicians should be aware of the systemic complications related to abnormal blood coagulation when treating patients with AIBD. Abstract : Several studies, including our previous study, have reported the risk of venous thromboembolism (VTE) in patients with autoimmune blistering disease (AIBD). However, we have also experienced multiple cases of pemphigus or pemphigoid that developed severe complications related to abnormal blood coagulation other than VTE, e.g. severe bleeding and cerebral infarction. This study summarizes those cases and discusses the risk of thromboembolism and bleeding in patients with AIBD.