Synthesis of Photosensitizers Based on Tetrapyrrolic Macrocycles for Combination with Antibiotics: Dual Inactivation of Bacteria. Issue 11 (9th November 2022)

• Record Type: Journal Article
• Authors: Aroso, Rafael T.; Piccirillo, Giusi; Dias, Lucas D.; Pinto, Sara M. A.; Arnaut, Luís G.; Pereira, Mariette M.
• Is Part Of: ChemPlusChem. Volume 87:Issue 11(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-09
• Subjects: antibiotics -- antimicrobial photodynamic therapy -- bacteria -- photosensitizers -- tetrapyrrolic macrocycles; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cplu.202200228
• Languages: English
• ISSNs: 2192-6506

Abstract

Abstract: The combination of photodynamic therapy with antibiotics or antimicrobial peptides for inactivation of bacteria is an area of growing interest due to the synergistic effect already observed by many authors. It has been shown that the efficiency of this dual antimicrobial therapy is highly dependent on the structure of the photosensitizer, being tetrapyrrolic macrocycles the ones with most promising results. There are a few review articles in the recent literature describing the main microbiological results concerning this dual inactivation of bacteria, but none of them focus on the synthetic processes of these photosensitizers and their remarkable chemical versatility. Therefore, herein we present an overview on synthetic methodologies for preparation of tetrapyrrolic macrocycles and their conjugates with antibiotics or antimicrobial peptides, for use in dual inactivation of bacteria. This review will be divided in two sections concerning the physical or covalent combinations of PS with antibiotic/cationic peptides, followed by brief critical analysis on their corresponding antimicrobial outcomes. Abstract : Tetrapyrroclic macrocycles are one of the most promising photosensitizers in combination with antibiotics for dual inactivation of bacteria. This Review provides an overview regarding synthetic approaches for tetrapyrrolic macrocycles used as photosensitizers for dual inactivation of bacteria as well as a critical analysis on their antimicrobial effects.Pinto, Pereira, and co‐workers @UnivdeCoimbra @uegoficial with a Review article discussing the synthesis of photosensitizers based on tetrapyrrolic macrocycles for combination with antibiotics #PhotodynamicTherapy