Hydrogen sulfide‐activatable fluorescence turn‐on azide‐containing naphthalimide derivative. (28th August 2022)

• Record Type: Journal Article
• Authors: Yoo, Song Yi; Gopala, Lavanya; Kang, Chulhun; Lee, Min Hee
• Is Part Of: Bulletin of the Korean Chemical Society. Volume 43:Number 11(2022)
• Page Start: 1231
• Page End: 1235
• Publication Date: 2022-08-28
• Subjects: azide‐containing naphthalimide -- fluorescent turn‐on probe -- hydrogen sulfide -- intramolecular charge transfer; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/bkcs.12611
• Languages: English
• ISSNs: 0253-2964

Abstract

Abstract: Hydrogen sulfide (H2 S) acts as a crucial biological and environmental component in a variety of processes. Abnormal levels of H2 S endogenously generated in human body are associated with various diseases. Meanwhile, H2 S gas leaked from various manufacturing environments has a fatal effect against the human body. For this reason, H2 S has been considered as a potential biomarker for the diagnosis and treatment of various human diseases, and as a toxic gas that should be detected when leaked to the workplace for the safety of workers. In this study, we synthesized an azide‐containing naphthalimide derivative that can play as a fluorescence turn‐on probe for H2 S. Abstract : A H2 S‐selective fluorescent turn‐on probe was developed based on azide‐containing naphthalimide derivative. The azide group was selectively converted to a primary amine by H2 S in aqueous solution, resulting in a fluorescence at 550 nm with chromogenic change. It was suggested that the probe can be utilized to detect H2 S under various biological and environmental assay conditions.