Challenges documenting racial disparities in Merkel cell carcinoma. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Martin, Mackenzie R.; Mohsin, Noreen; Vilasi, Serena; Reed, Danielle; Brownell, Isaac
• Is Part Of: Cancer biology & therapy. Volume 23:Issue 1(2022)
• Page Start: 1
• Page End: 3
• Publication Date: 2022-12-31
• Subjects: Merkel cell carcinoma -- health disparities -- racial disparities -- immunotherapy -- survival -- tumor registries -- skin cancer -- rare diseases; 616.99406
• DOI: 10.1080/15384047.2022.2145842
• Languages: English
• ISSNs: 1538-4047

Abstract

ABSTRACT: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer that predominantly impacts White patients. Overall incidence and the proportion of minority patients with MCC are both rising. In the more common skin cancer, melanoma, racial disparities are well-documented in stage at presentation and patient survival. Whether racial and ethnic disparities exist in MCC remains unclear. The study of MCC disparities is hampered by limitations in data registries, including SEER and NCDB, and an evolving natural history due to the advent of immunotherapy. Published MCC immunotherapy clinical trials consistently reported the racial diversity among enrolled subjects but failed to include patients' ethnicities. Efforts to improve data capture in cancer registries and create multi-institutional clinical databases will allow for more effective study of racial and ethnic disparities in rare cancers like MCC. Such studies are needed to advance policies promoting equity in care.