Antibacterial flavonoids from the fruits of Macaranga hurifolia. Issue 11 (2nd November 2022)

• Record Type: Journal Article
• Authors: Pagna, Julio Issah Mawouma; Awazi, Tengu; Mbarga, Paul Etoga; Mbekou, Ines Michèle Kanko; Mkounga, Pierre; Fotie, Jean; Frese, Marcel; Fabrice, Fekam Boyom; Lenta, Bruno Ndjakou; Sewald, Norbert; Nkengfack, Ephrem Augustin
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 11(2022)
• Page Start: 1041
• Page End: 1051
• Publication Date: 2022-11-02
• Subjects: Macaranga hurifolia -- Euphorbiaceae -- flavonoids -- antibacterial activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.2019223
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: As part of our search for new secondary metabolites from Macaranga hurifolia Beille, a phytochemical investigation was carried out on the fruits that led to the isolation and characterization of two new prenylated flavonol derivatives named macafolias A (1 ) and B (2 ), along with five known compounds. Their chemical structures were established on the basis of extensive analysis of their 1–D and 2–D NMR ( 1 H, 13 C, APT, COSY, HSQC and HMBC) in conjunction with mass spectroscopy and by comparison with data from the literature. The in vitro assay of the antibacterial potency of the crude extract, fractions and some pure compounds were evaluated against a wide range of bacteria strains. Graphical Abstract: UF0001