Rhodomollosides A and B, glycosides of methyl everninate from the aerial parts of Rhododendron molle. Issue 11 (2nd November 2022)

• Record Type: Journal Article
• Authors: Yang, Xue-Rong; Tanaka, Naonobu; Song, Jing-Ru; Lu, Feng-Lai; Yan, Xiao-Jie; Li, Jian-Xing; Zhao, Xue-Ying; Kashiwada, Yoshiki; Li, Dian-Peng
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 11(2022)
• Page Start: 1025
• Page End: 1032
• Publication Date: 2022-11-02
• Subjects: Rhododendron molle -- Eriaceae -- glycosides of methyl everninate -- D-allose -- rhodomollosides A and B; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.2011241
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new glycosides of methyl everninate, rhodomollosides A (1 ) and B (2 ), were isolated from the aerial parts of a medicinal plant Rhododendron molle . The structures of 1 and 2 were elucidated on the basis of detailed spectroscopic analyses as well as HPLC analyses for thiazolidine derivatives of their sugar moieties. The sugar moiety of rhodomolloside A (1 ) was elucidated to be a rare monosaccharide, D-allose, while rhodomolloside B (2 ) was assigned as a D-glucoside of methyl everninate. Furthermore, they were evaluated for their cytotoxicity against RAW264.7 cells, and for their inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model. Graphical Abstract: UF0001