A DNA–Au nanomachine activated by dual types of biomarkers for multi-site imaging and gene silencing. Issue 94 (8th November 2022)

• Record Type: Journal Article
• Authors: Zhou, Yanmei; Li, Zhaoge; Wu, Tian; Ning, Juan; Hu, Guizhen; Nie, Yamin
• Is Part Of: Chemical communications. Volume 58:Issue 94(2022)
• Page Start: 13107
• Page End: 13110
• Publication Date: 2022-11-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc05017j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A programmed DNA–Au nanomachine was constructed to achieve in situ imaging of the transmembrane glycoprotein MUC1 and cytoplasmic miRNA-21 and trigger precise gene silencing therapy for breast cancer. Abstract : A programmed DNA–Au nanomachine has been constructed to achieve in situ imaging of transmembrane glycoprotein MUC1 and cytoplasmic miRNA-21 and trigger gene silencing therapy. The results of MCF-7 cell-specific imaging and apoptosis experiments demonstrate that the nanomachine provides a valuable nanotheranostic platform for accurate multi-site imaging and intracellular gene silencing.