Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired. (3rd October 2022)

• Record Type: Journal Article
• Authors: Lehtola, Juha-Matti; Kärkkäinen, Virve; Andberg, Sami; Hannonen, Sanna; Rusanen, Minna; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Kaarniranta, Kai; Bednarik, Roman; Leinonen, Ville; Koivisto, Anne M.
• Is Part Of: Alzheimer disease and associated disorders. Volume 36:Number 4(2022)
• Page Start: 340
• Page End: 346
• Publication Date: 2022-10-03
• Subjects: idiopathic normal pressure hydrocephalus (iNPH) -- Alzheimer's disease (AD) -- biomarker -- saccadic eye movements -- eye tracking (ET) -- King-Devick (KD); Alzheimer's disease -- Periodicals; Dementia -- Periodicals; 616.8305
• DOI: 10.1097/WAD.0000000000000527
• Languages: English
• ISSNs: 0893-0341

Abstract

Abstract : Background: Functional defects in eye movements and reduced reading speed in neurodegenerative diseases represent a potential new biomarker to support clinical diagnosis. We investigated whether computer-based eye-tracking (ET) analysis of the King-Devick (KD) test differentiates persons with idiopathic normal pressure hydrocephalus (iNPH) from cognitively unimpaired [control (CO)] and persons with Alzheimer's disease (AD). Methods: We recruited 68 participants (37 CO, 10 iNPH, and 21 AD) who underwent neurological examination, the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological test battery (CERAD-NB), and a Clinical Dementia Rating interview. The KD reading test was performed using computer-based ET. We analyzed the total time used for the reading test, number of errors, durations of fixation and saccade, and saccade amplitudes. Results: The iNPH group significantly differed from the CO group in the KD test mean total time (CO 69.3 s, iNPH 87.3 s; P ≤0.009) and eye-tracking recording of the mean saccade amplitude (CO 3.6 degree, iNPH 3.2 degree; P ≤0.001). The AD group significantly differed from the CO group in each tested parameter. No significant differences were detected between the iNPH and AD groups. Conclusion: For the first time, we demonstrated altered reading ability and saccade amplitudes in patients with iNPH.