INCIDENCE, RISK FACTORS, AND OUTCOME OF SUSPECTED CENTRAL VENOUS CATHETER-RELATED INFECTIONS IN CRITICALLY ILL COVID-19 PATIENTS: A MULTICENTER RETROSPECTIVE COHORT STUDY. Issue 5 (8th November 2022)

• Record Type: Journal Article
• Authors: Smit, Jasper M.; Exterkate, Lotte; van Tienhoven, Arne J.; Haaksma, Mark E.; Heldeweg, Micah L.A.; Fleuren, Lucas; Thoral, Patrick; Dam, Tariq A.; Heunks, Leo M.A.; Gommers, Diederik; Cremer, Olaf L.; Bosman, Rob J.; Rigter, Sander; Wils, Evert-Jan; Frenzel, Tim; Vlaar, Alexander P.; Dongelmans, Dave A.; de Jong, Remko; Peters, Marco; Kamps, Marlijn J.A; Ramnarain, Dharmanand; Nowitzky, Ralph; Nooteboom, Fleur G.C.A.; de Ruijter, Wouter; Urlings-Strop, Louise C.; Smit, Ellen G.M.; Mehagnoul-Schipper, D. Jannet; Dormans, Tom; de Jager, Cornelis P.C.; Hendriks, Stefaan H.A.; Achterberg, Sefanja; Oostdijk, Evelien; Reidinga, Auke C.; Festen-Spanjer, Barbara; Brunnekreef, Gert B.; Cornet, Alexander D.; van den Tempel, Walter; Boelens, Age D.; Koetsier, Peter; Lens, Judith; Faber, Harald J.; Karakus, A.; Entjes, Robert; de Jong, Paul; Rettig, Thijs C.D.; Arbous, Sesmu; Vonk, Bas; Machado, Tomas; Girbes, Armand R.J.; Sieswerda, Elske; Elbers, Paul W.G.; Tuinman, Pieter R.;
• Is Part Of: Shock. Volume 58:Issue 5(2022)
• Page Start: 358
• Page End: 365
• Publication Date: 2022-11-08
• Subjects: Central venous catheters -- catheter-related infections -- COVID-19 -- intensive care; Shock -- Periodicals; Shock -- Periodicals; Choc (Pathologie) -- Périodiques; Shock; Periodicals; 616.0475
• DOI: 10.1097/SHK.0000000000001994
• Languages: English
• ISSNs: 1073-2322

Abstract

ABSTRACT: Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1, 000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12–11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25–2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.