Hemodynamic response to intestinal pH stimulation measured with spectroscopic video imaging. (1st January 2023)

• Record Type: Journal Article
• Authors: Funane, Tsukasa; Yokoi, Yuki; Kiguchi, Masashi; Shinozaki, Ryuga; Ayabe, Tokiyoshi; Atsumori, Hirokazu; Nishimura, Ayako; Nakamura, Kiminori; Kandori, Akihiko
• Is Part Of: Biomedical physics & engineering express. Volume 9:Number 1(2023)
• Publication Date: 2023-01-01
• Subjects: gut-skin axis -- hemodynamic response -- spectroscopic video imaging -- blood proteome analysis; Medical physics -- Periodicals; Biophysics -- Periodicals; Biomedical engineering -- Periodicals; Medical sciences -- Periodicals; 610.153
• DOI: 10.1088/2057-1976/aca20a
• Languages: English
• ISSNs: 2057-1976

Abstract

Abstract: To investigate the relationship between the gut and skin (gut-skin axis), head skin hemodynamic responses to gut stimulation including the injection of acetic acid in nude mice were measured by spectroscopic video imaging, which was calculated using a modified Beer-Lambert formula. The relationship with blood proteins was also analyzed. The blood volume changes in three mice injected with acetic acid were highly reproducible in the mathematical model equation. Four proteins correlated with blood volume changes were all related to immunity. These results suggest that intestinal pH can alter the blood volume in the skin and induce immune-related responses.