Pregnancy after CMV infection following uterus transplantation: A case report from the Dallas Uterus Transplant Study. Issue 4 (13th June 2021)

• Record Type: Journal Article
• Authors: Rosenzweig, Matthew; Wall, Anji; Spak, Cedric W.; Testa, Giuliano; Johannesson, Liza
• Is Part Of: Transplant infectious disease. Volume 23:Issue 4(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-13
• Subjects: cytomegalovirus -- live birth -- pregnancy -- uterus transplantation; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13653
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Uterus transplantation is a repeatedly proven treatment for women with absolute uterine‐factor infertility, which is the congenital or acquired absence of the uterus, who desire to carry, and ultimately deliver, a child. No stranger to the field of transplant or obstetrics is cytomegalovirus. Cytomegalovirus is both a frequent complication after transplant, presenting as an opportunistic infection, and a common congenital disease in the newborn child from pregnancy. To date, there have been no reported cases of pregnancy following uterus transplantation from cytomegalovirus‐positive donors into cytomegalovirus‐negative recipients. We present a case report describing our experience of a cytomegalovirus‐negative recipient, transplanted with a uterus from a cytomegalovirus‐positive living donor, and subsequently diagnosed with active cytomegalovirus infection despite prophylactic treatment. She was treated for infection prior to embryo transfer and carried a healthy child to term. This case suggests transplanting a cytomegalovirus‐positive uterus into a negative donor is possible to do safely.