Effect of coagulation function on cerebral microbleeds in intracerebral hemorrhage. Issue 6 (19th April 2020)

• Record Type: Journal Article
• Authors: Zhang, Hui; Deng, Jian; Sun, Nianlong; Zou, Liangyu; Han, Jing; Wei, Chen; He, Yitao
• Is Part Of: Brain and behavior. Volume 10:Issue 6(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-19
• Subjects: activated partial thromboplastin time -- cerebral microbleeds -- coagulation function -- intracerebral hemorrhage; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.1634
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Objective: Our study aimed to confirm whether coagulation function of patients presenting with intracerebral hemorrhage (ICH) was associated with onset of cerebral microbleeds (CMBs). Methods: A total of 174 patients with basal ganglia ICH were divided into CMBs and non‐CMBs groups. Indicators of coagulation function and other clinical data that included fibrinogen (FBI), prothrombin time (PT), activated partial thromboplastin time (APTT), and the international normalized ratio (INR) were compared by univariate and multivariate analysis between the two groups. A receiver operating characteristic (ROC) curve was plotted to determine the predictive value of coagulation function indicators for CMBs. Results: Univariate analysis showed that APTT levels was significantly higher in the CMBs group than the non‐CMBs group (30.20 ± 5.18 vs. 27.95 ± 4.19; p = .004), while there was no significant difference between PT, INR, and FBI. The proportion of male patients in the CMBs group was significantly higher than the non‐CMBs group (76.58% vs. 52.38%, p = .001). Multifactor logistic regression analysis demonstrated that APTT and male gender were independent risk factors for CMBs in patients with ICH (OR 1.100, 95% CI: 1.026–1.180, p = .008; OR 2.957, 95% CI: 1.500–5.826, p = .002; respectively). ROC curve analysis indicated that the area under the curve of APTT and male gender for CMBs in patients with ICH was 0.641 and 0.621, respectively ( p = .002 and .008; respectively). Conclusion: APTT was an independent risk factor for CMBs in patients with ICH. Abstract : (a) Activated partial thromboplastin time was an independent risk factor for CMBs in patients with intracerebral hemorrhage (ICH); (b) international normalized ratio and fibrinogen were not independent risk factor for CMBs in patients with ICH.