Successful cord blood transplantation for myelodysplastic syndrome complicated by Mycobacterium kansasii pneumonia. Issue 4 (2nd June 2021)

• Record Type: Journal Article
• Authors: Yamada, Arisa; Akahane, Daigo; Katagiri, Seiichiro; Yoshizawa, Seiichiro; Furuya, Nahoko; Fujimoto, Hiroaki; Gotoh, Moritaka; Gotoh, Akihiko
• Is Part Of: Transplant infectious disease. Volume 23:Issue 4(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-02
• Subjects: cord blood transplantation -- Mycobacterium kansasii -- myelodysplastic syndrome -- non‐tuberculous mycobacterial disease; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13463
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Non‐tuberculous mycobacterial (NTM) disease is a rare cause of neutropenic fever in patients with hematological malignancies. There are few studies on the optimal management for such patients with NTM. We report a case of myelodysplastic syndrome (MDS) treated by umbilical cord blood transplantation (CBT) after Mycobacterium kansasii ( M kansasii ) pneumonia. A 38‐year‐old man diagnosed with MDS developed severe pneumonia during induction chemotherapy. Repeated sputum culture uncovered mycobacterium infection. Then, by the polymerase chain reaction of the bronchial lavage fluid, M kansasii infection was proven. After 140 days of anti‐NTM therapy, CBT was successfully carried out and the patient recovered without recurrence of NTM infection. This case provides valuable evidence that hematopoietic stem cell transplantation is feasible after a reliable diagnosis and continuous anti‐NTM therapy.