Glucose‐Induced Disintegrated Hydrogel for the Glucose‐Responsive Delivery of Insulin. Issue 42 (9th November 2021)

• Record Type: Journal Article
• Authors: Lu, Yangyang; Yu, Haojie; Wang, Li; Shen, Di; Liu, Jian
• Is Part Of: ChemistrySelect. Volume 6:Issue 42(2021)
• Page Start: 11664
• Page End: 11674
• Publication Date: 2021-11-09
• Subjects: Drug delivery -- Glucose-responsive -- Injectable hydrogel -- Phenylboronic acid -- Proteins; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202102778
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Stimulus‐sensitive drug delivery materials are of vital significance to modern therapeutic technology. In particular, glucose‐responsive hydrogels capable of biomimetic release of hypoglycemic drugs according to glucose concentrations are one of the current research hotspots. In this paper, an injectable, glucose‐induced disintegrated natural‐polysaccharide‐based hydrogel with good self‐healing ability and biocompatibility is reported. The glucose‐responsiveness of the hydrogel stems from the reversible phenylborate ester bonds. The glucose‐triggered disintegration and insulin release are demonstrated in the hydrogel in a physiological environment. The two polymers produced by the disintegration of the hydrogel have good biocompatibility and biodegradability. Therefore, the hydrogel is considered to result in the development of smart insulin delivery systems. Abstract : Dynamically crosslinked hydrogels were prepared via the combination of 4‐carboxy‐3‐fluorophenylboronic grafted chitooligosaccharides (CSPBA) and guar gum (GG). The reversible phenylborate ester bonds between PBA on CSPBA and galactose/mannose residues on GG drove the formation of the hydrogel. The CSPBA/GG hydrogels had good injectability and self‐healing ability due to the dynamically reversible crosslinking. What's more, the CSPBA/GG hydrogel exhibited glucose‐induced disintegration and glucose concentration‐dependent insulin release because of the glucose‐sensitivity of phenylborate ester bonds.